LAST year, the idea of opening a luxury spa at the Plaza Hotel in Manhattan sounded like a perfect business opportunity to Mathilde and Bertrand Thomas, the founders of the French skin-care company Caudalie. Their goal was to create a luxurious haven for their grape- and wine-based spa treatments, along the lines of Caudalie’s original spa on the grounds of Château Smith Haut Lafitte, a grand cru winery in Bordeaux owned by Ms. Thomas’s parents.

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