In a city like New York, there are many reasons to pick a particular watering hole: a sympathetic bartender, a selective jukebox, the collection of patrons bellied up alongside you. But for Kate Hughes and Toni Suppa, friends since high school, it was the guilty pleasures of TV’s “Gossip Girl” that helped lure them on a recent evening to the Lobby Bar of the Empire Hotel on West 63rd Street, a fixture in the series about hard-partying Upper East Side teenagers.

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